ArticleResuscitation plus2025
Adrenaline and return of spontaneous circulation during in-hospital cardiac arrest.
Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Introduction: Adrenaline provides inotropic, chronotropic and vasopressor effects and is a cornerstone drug during cardiopulmonary resuscitation. This study of in-hospital cardiac arrest aimed to investigate the effect of adrenaline on the return of spontaneous circulation (ROSC) in primary pulseless electrical activity (PEA). Method: In-hospital cardiac arrests episodes at St. Olav University Hospital (Norway) were prospectively registered between 2018 and 2022, among these were 73 episodes with primary PEA. Time of adrenaline administration was obtained with minutes precision by reviewing the clinical record and interviewing personnel, thereby establishing a consistent timeline. We investigated transitions from primary PEA to ROSC following adrenaline administration using time-to-event models. Results: Adrenaline exerted its maximum effect between 45 and 85 s after administration and strongly favored the transition from primary PEA to ROSC, with an intensity ratio of 5.03 ( Conclusion: We found a rapid and five-fold increase in the transition intensity from primary PEA to ROSC approximately one minute after adrenaline administration. Repeated doses in the absence of an initial response did not alone increase the transition probability.
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