ArticleBioactive materials2026
Sustainability of functional hair follicle activity: Impact of spatially anchored multifunctional tetrahedral framework nucleic acids.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Organoid-loaded core-shell cryomicroneedles induce biomimetic follicular units and hair regeneration.Bioactive materials · 2026Article
- Human Secretomes, Plant Exosomes, and Hybrid Secretomes Intradermal Injections for Hair Regeneration: Experimental Study.Plastic and reconstructive surgery. Global open · 2026Article
- Tetrahedral framework nucleic acids carrying tranexamic acid to alleviate ultraviolet B-induced skin pigmentation.Materials today. Bio · 2026Article
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Authors and funding
5 authors.
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Abstract
Alopecia is a physical and mental health problem affecting all age groups, aesthetically or psychologically. Among its subtypes, androgenetic alopecia (AGA) is the most prevalent. This androgen-dependent, polygenic disease is hereditary and can occur as early as adolescence. Currently available therapies remain largely palliative and are often accompanied by adverse side effects. Here, we constructed a multifunctional system based on tetrahedral framework nucleic acids (tFNAs), in which quercetin was embedded within tFNAs to form a complex termed tFNAs-Que (TQC). We performed multimodal analysis, combined with transcriptomic analysis, to explore the activation and sustainable changes in the hair follicle cycle after TQC treatment. Our results showed that TQC maintained the stability of the epithelial structure and enhanced the regeneration of functional hair follicles by regulating both hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Additionally, we identified a catalytic role of tFNAs. Overall, this study developed a dual-regulated nucleic acid nanoparticle, opening up new avenues for clinical translation in activating, stabilizing, and sustaining the hair cycle.
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