Evidence map›Paper›PMID 41323201›Full record

ArticleBioactive materials2026

Infection responsive bio-nanoparticles as "molecular sprayer " for infection-repair integration via direct sterilization and macrophage polarization regulation.

Cheng-Jie Ma, Zhi Peng, Rui Xu, Jun-Hua Fang, Han-Ying Wang, Xiong-Gang Yang, Yu-Ling Li, Dong-Yuan Zhang, Zhi-Qiang Li, Yu Zhao and 2 more

Abstract read
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In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheng-Jie MaDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Zhi PengDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Rui XuDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Jun-Hua FangDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Han-Ying WangSchool of Basic Medical Sciences, Kunming Medical University, Kunming, China.
Xiong-Gang YangDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Yu-Ling LiDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Dong-Yuan ZhangDepartment of Nutrition and Health, China Agricultural University, Beijing, China.
Zhi-Qiang LiMOE Key Laboratory of Bioinformatics, Tsinghua University, Beijing, China.
Yu ZhaoDepartment of Orthopedics Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jian-Hong HouDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.
Sheng LuDepartment of Orthopedics, The First People's Hospital of Yunnan Province & the Affiliated Hospital of Kunming University of Science and Technology, The Key Laboratory of Digital Orthopedics of Yunnan Province, The Clinical Medicine Center of Spinal and Spinal Cord Disorders Of Yunnan Province, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue destruction and related complications caused by bacterial infection remain a major challenge in clinical treatment. Existing therapies generally fail to balance the process of infection control and tissue repair simultaneously. In this study, infection microenvironmental-responsive multifunctional "molecular sprayer" nanocomposites (NP@D/AMP) were developed by loading 2-(1, 8-naphthidine -2-yl) phenol (2-NP) onto dendritic mesoporous silica nanoparticles (DMSNs), then encapsulating GW18 with polydopamine for sealing, which achieved the integrated functions of antibacteria, immune regulation and promoting bone formation. NP@D/AMP can sequentially release GW18 and 2-NP under the acidic microenvironment at the infectious site, where GW18 shows strong antibacterial and biofilm inhibition ability against

Indexed as

AntibacteriaBone infectionMacrophage polarizationMolecular sprayerOsteogenic differentiation

Identifiers

PMID41323201
PMCPMC12661343

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.