Evidence map›Paper›PMID 41323198›Full record

ArticleBioactive materials2026

Bilayer vascular grafts separately loaded with sodium copper chlorophyllin and keratin-based hydrogen sulfide donor with pro-endothelialization, anti-thrombogenicity, anti-inflammation, and anti-calcification properties.

Yu Sun, Shunqi Hu, Lijuan Wang, Fubang Liang, Zeyi Zhou, Yuyuan Zhang, Yanjun Pan, Jian Shen, Meng Yin, Jiang Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Application of PLCL as a biodegradable polymer in biomedical engineering.Journal of materials science. Materials in medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yu SunJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China.
Shunqi HuDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, PR China.
Lijuan WangJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China.
Fubang LiangDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, PR China.
Zeyi ZhouDepartment of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, PR China.
Yuyuan ZhangWisdom Lake Academy of Pharmacy, Xi'an Jiaotong-Liverpool University, Suzhou, PR China.
Yanjun PanDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, PR China.
Jian ShenJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China.
Meng YinDepartment of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai, 200127, PR China.
Jiang YuanJiangsu Collaborative Innovation Center of Biomedical Functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical utility of small-diameter vascular grafts (SDVGs) remains limited due to thrombosis, inflammation, and intimal hyperplasia, which compromise long-term patency. Mimicking the structures and functions of blood vessels, bilayer SDVGs with gradient pore sizes were fabricated, thereby preventing the infiltration of vascular smooth muscle cells (VSMCs) into the inner layer. Additionally, sodium copper chlorophyllin (SCC) was embedded in the inner layer, potentially generating NO from endogenous donors in the blood and regulating vascular cells. Keratin-based H

Indexed as

EndothelializationHydrogen sulfideNitric oxideSmall-diameter vascular grafts

Identifiers

PMID41323198
PMCPMC12661995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.