ArticleFood & nutrition research2025
Causal relationships between 25-hydroxyvitamin D levels and laryngeal cancer risk: A two-sample Mendelian randomization study.
Article in Food & nutrition research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: The relationship between 25-hydroxyvitamin D (25(OH)D) levels and the risk of laryngeal cancer (LC) is unclear. This study aimed to explore the causal association between 25(OH)D levels and LC risk using the two-sample Mendelian randomization (MR) analysis. Methods: Single-nucleotide polymorphisms for 25(OH)D levels and LC were extracted from published genome-wide association studies (GWAS) or the Medical Research Council Integrative Epidemiology Unit (MRC-IEU) Open GWAS project. Univariable MR and multivariable MR analyses were performed. Five MR methods including MR-Egger, weighted-median, inverse-variance weighted (IVW), simple mode, and weighted mode were applied. Results: Univariable MR analysis identified the fact that genetically predicted higher levels of 25(OH)D were associated with lower odds of LC [IVW: (odds ratio (OR) = 0.9993, 95% confidence interval (CI), 0.9987-0.9999; Conclusions: This MR analyses supported a slight protective effect of higher levels of 25(OH)D on the risk of LC.
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