ArticleFood & nutrition research2025
Causal relationships of serum iron metabolites with sepsis and cardiomyopathy: a Mendelian randomization analysis.
Article in Food & nutrition research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Article
- Sepsis-induced cardiomyopathy: mechanisms, epidemiology, diagnosis, and treatments.Frontiers in immunology · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study aims to investigate the causal relationships of serum iron (SI) metabolites with sepsis and cardiomyopathy as two distinct outcomes. Methods: Genome-wide association studies (GWAS) data for SI, serum ferritin (SF), serum transferrin (STF), transferrin receptor (TFRC), sepsis, and cardiomyopathy were obtained from the EBI website. Transferrin saturation percentage (TSP) data were from the Genetics of Iron Status Consortium. Due to lack of GWAS for acute sepsis-induced cardiomyopathy (SIC), cardiomyopathy GWAS was used as a genetic proxy. Causal relationships were analysed using inverse-variance weighting, MR-Egger, weighted median, simple mode, and weighted mode methods. Power calculations, Cochran's Q test, MR-PRESSO, and Steiger directionality test were performed for quality control. Results: In the analysis of iron metabolites and cardiomyopathy, there were 2 single nucleotide polymorphisms (SNPs) in SI (mean Conclusion: SF may increase the risk of both sepsis and cardiomyopathy, potentially through inflammation-iron metabolism pathways rather than direct iron toxicity.
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Registered trials
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