ArticleAnesthesiology research and practice2025
MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.
Article in Anesthesiology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- ISO-1 sustained-release hydrogel repairs infected bone defects by suppressing osteoblast pyroptosis and enhancing osteogenic differentiation via the MIF-CD74/PI3K/AKT signaling pathway.Materials today. Bio · 2026Article
- SIRT6 activation relieves neuropathic pain by restoring Nrf2 signaling and inhibiting NLRP3 inflammasome.Frontiers in physiology · 2026Article
- MIF-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Spinal Neurons and Microglial Polarization Facilitate Neuropathic Pain Progression.Anesthesiology research and practice · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite considerable advancements in therapeutic approaches, neuropathic pain remains a globally prevalent and challenging source of chronic suffering, underscoring the urgent demand for innovative treatment strategies. Here, we investigated the role of macrophage migration inhibitory factor (MIF) in neuropathic pain using a rodent model of chronic constriction injury (CCI) to the sciatic nerve, approved by the Ethical Committee of Animal Use and Care. Mechanical thresholds (von Frey hairs) and thermal latencies (hot plate) were measured, alongside spinal MIF expression, pyroptosis markers (e.g., GSDMD-N), and inflammatory cytokines (IL-1β, IL-6, and TNF-α). Our results showed that spinal MIF levels surged post-CCI, peaking on day 14 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.