Evidence map›Paper›PMID 41323095›Full record

ArticleInternational journal of endocrinology2025

Association Between Serum G Protein-Coupled Estrogen Receptor and the Peripheral Blood Balance of T-Helper/New Effector T-Cells in Patients With Hashimoto's Thyroiditis.

Xiu Zang, Wenruo Chen, Ran Liu, Yanhong Lin, Xuekui Liu, Houfa Geng, Jun Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiu ZangDepartment of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, Jiangsu, China.ORCID https://orcid.org/0000-0001-9425-747X
Wenruo ChenThe Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Ran LiuThe Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Yanhong LinThe Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Xuekui LiuDepartment of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, Jiangsu, China.
Houfa GengDepartment of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou, Jiangsu, China.
Jun LiangThe Affiliated Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China.ORCID https://orcid.org/0009-0005-8115-4910

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the effects of the G protein-coupled estrogen receptor (GPER) on the balance of regulatory T-helper/new effector T-cells (Treg/Th17) in the peripheral blood of patients with Hashimoto's thyroiditis (HT) and healthy individuals. Methods: A total of 230 participants were enrolled in this study, including 206 patients with new-onset HT (HT group) and 24 healthy physical examinees (normal control [NC] group). Venous blood samples were obtained from the participants and tested for serum GPER levels using an enzyme-linked immunosorbent assay. The peripheral blood proportion of Treg and Th17 cells and the Treg/Th17 ratio were determined using flow cytometry. Thyroid function, antibody levels, and biochemical and anthropometric tests were performed. Data management and statistical analyses were performed using SPSS Version 25.0. Results: The serum GPER levels among the HT group participants were significantly higher than those among the NC group ( Conclusion: The results confirmed that the serum GPER expression level in the initial HT group was significantly higher than that in the NC group and was positively correlated with the Treg/Th17 ratio, peroxidase antibody, and thyroglobulin antibody. Our findings suggest that a compensatory increase in the proportion of Treg/Th17 cells may be related to increased serum GPER levels.

Indexed as

G protein–coupled estrogen receptorHashimoto's thyroiditisTh17 cellsTreg cellsTreg/Th17 ratio

Identifiers

PMID41323095
PMCPMC12662672

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.