Evidence map›Paper›PMID 41323021›Full record

Trial reportJournal of immunology research2025

Failure of γδ T Cell Recovery in the Gut With Effective Anti-HIV Therapy.

Priscila O Barros, Stephanie C Burke Schinkel, Ameeta Lubina Nayak, Brittany Haas, Tamara K Berthoud, Michaeline McGuinty, D William Cameron, Jonathan B Angel

Abstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Priscila O BarrosInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.ORCID https://orcid.org/0000-0002-6173-0416
Stephanie C Burke SchinkelInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.
Ameeta Lubina NayakInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.
Brittany HaasInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.
Tamara K BerthoudInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.
Michaeline McGuintyDepartment of Medicine, Division of Infectious Diseases, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada, uottawa.ca.
D William CameronInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.
Jonathan B AngelInflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, ohri.ca.ORCID https://orcid.org/0000-0003-3102-4462

Funding

Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
NIAID NIH HHS U24 AI126683
6 · The paper itself

Abstract

Introduction: Infection with HIV alters γδ T cells, and while these changes have been well documented in blood, they are less well understood in the gut. Methods: Phenotype (specifically HIV coreceptor expression) and polyfunctionality, as defined by concomitant cytokine expression, were evaluated in γδ T cells in the blood and gut of effectively treated people living with HIV (PLWH) and people without HIV (PWOH). Mononuclear cells were isolated from blood and recto-sigmoid colon biopsy tissue, and γδ T cells were evaluated by flow cytometry. Results: The expression of α4β7 was significantly higher in gut-derived γδ T cells of PLWH compared to PWOH and blood-derived cells of both groups. The polyfunctionality profile of gut-derived γδ T cells in PLWH was also different than that of PWOH, with significantly higher expression of IFN-γ in the gut-derived cells. Conclusion: The alterations observed in gut-derived γδ T cells from effectively treated PLWH suggest cellular function is not restored with prolonged antiretroviral therapy (ART) and may contribute to a chronic inflammatory state.

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsIntraepithelial LymphocytesReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsAdultCytokinesFemaleHumansIntegrinsInterferon-gammaMaleMiddle AgedAnti-HIV AgentsCytokinesintegrin alpha4beta7IntegrinsInterferon-gammaReceptors, Antigen, T-Cell, gamma-deltaalpha 4 beta 7 integrin (α4β7)cytokine polyfunctionalityhuman immunodeficiency virus (HIV)recto-sigmoid colon biopsyγδ T cells

Identifiers

PMID41323021
PMCPMC12658385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.