Evidence map›Paper›PMID 41322985›Full record

ArticleFrontiers in cellular and infection microbiology2025

Isoliquiritigenin Attenuates

Lili Tian, Jian Sun, Hong Jiang, Hongjun Wang, Jian Zheng, Dacheng Wang, Libo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lili Tian *College of Animal Science and Veterinary Medicine (Affiliated Animal Hospital), Jinzhou Medical University, Jinzhou, Liaoning, China.
Jian Sun *Department of Animal Husbandry and Veterinary Medicine, Beijing Vocational College Agriculture, Beijing, China.
Hong JiangCollege of Animal Science and Veterinary Medicine (Affiliated Animal Hospital), Jinzhou Medical University, Jinzhou, Liaoning, China.
Hongjun WangCollege of Animal Science and Veterinary Medicine (Affiliated Animal Hospital), Jinzhou Medical University, Jinzhou, Liaoning, China.
Jian ZhengCollege of Animal Science and Veterinary Medicine (Affiliated Animal Hospital), Jinzhou Medical University, Jinzhou, Liaoning, China.
Dacheng WangCollege of Animal Science, Jilin University, Changchun, China.
Libo ZhangCollege of Animal Science and Veterinary Medicine (Affiliated Animal Hospital), Jinzhou Medical University, Jinzhou, Liaoning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methicillin-resistant Methods: The inhibitory effect of isoliquiritigenin (ISL) on Results: ISL inhibited SrtA activity in a dose-dependent manner (IC Discussion: ISL effectively attenuates MRSA pathogenicity by targeting SrtA-mediated virulence rather than bacterial viability. These results highlight ISL as a promising antivirulence agent and a potential adjuvant for combating antibiotic-resistant S. aureus infections.

Indexed as

Anti-Bacterial AgentsBacterial AdhesionChalconesMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsStaphylococcus aureusAminoacyltransferasesAnimalsBacterial LoadBacterial ProteinsBiofilmsCysteine EndopeptidasesDisease Models, AnimalFemaleMiceMice, Inbred BALB CAminoacyltransferasesAnti-Bacterial AgentsBacterial ProteinsChalconesCysteine Endopeptidasesisoliquiritigeninsortase Aantibiotic resistanceantivirulence therapyisoliquiritigeninmethicillin-resistant staphylococcus aureuspneumoniasortase A

Identifiers

PMID41322985
PMCPMC12660299

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.