Evidence map›Paper›PMID 41322981›Full record

ReviewFrontiers in big data2025

Achieving health equity in immune disease: leveraging big data and artificial intelligence in an evolving health system landscape.

Stan Kachnowski, Asif H Khan, Shadé Floquet, Kendal K Whitlock, Juan Pablo Wisnivesky, Daniel B Neill, Irene Dankwa-Mullan, Gezzer Ortega, Moataz Daoud, Raza Zaheer and 2 more

Abstract readReview
In one paragraph

Review in Frontiers in big data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stan Kachnowski *Healthcare Innovation and Technology Lab, New York, NY, United States.
Asif H Khan *Sanofi, Morristown, NJ, United States.
Shadé FloquetSanofi, Cambridge, MA, United States.
Kendal K WhitlockWalgreens Boots Alliance, New York, NY, United States.
Juan Pablo WisniveskyDivision of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Daniel B NeillCourant Institute of Mathematical Sciences, Department of Computer Science, New York University, New York, NY, United States.
Irene Dankwa-MullanDepartment of Health Policy and Management, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.
Gezzer OrtegaCenter for Surgery and Public Health, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Moataz DaoudSanofi, Cambridge, MA, United States.
Raza ZaheerSanofi, Cambridge, MA, United States.
Maia HightowerVeritas Healthcare Insights, Park City, UT, United States.
Paul RoweSanofi, Morristown, NJ, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prevalence of immune diseases is rising, imposing burdens on patients, healthcare providers, and society. Addressing the future impact of immune diseases requires "big data" on global distribution/prevalence, patient demographics, risk factors, biomarkers, and prognosis to inform prevention, diagnosis, and treatment strategies. Big data offer promise by integrating diverse real-world data sources with artificial intelligence (AI) and big data analytics (BDA), yet cautious implementation is vital due to the potential to perpetuate and exacerbate biases. In this review, we outline some of the key challenges associated with achieving health equity through the use of big data, AI, and BDA in immune diseases and present potential solutions. For example, political/institutional will and stakeholder engagement are essential, requiring evidence of return on investment, a clear definition of success (including key metrics), and improved communication of unmet needs, disparities in treatments and outcomes, and the benefits of AI and BDA in achieving health equity. Broad representation and engagement are required to foster trust and inclusivity, involving patients and community organizations in study design, data collection, and decision-making processes. Enhancing technical capabilities and accountability with AI and BDA are also crucial to address data quality and diversity issues, ensuring datasets are of sufficient quality and representative of minoritized populations. Lastly, mitigating biases in AI and BDA is imperative, necessitating robust and iterative fairness assessments, continuous evaluation, and strong governance. Collaborative efforts to overcome these challenges are needed to leverage AI and BDA effectively, including an infrastructure for sharing harmonized big data, to advance health equity in immune diseases through transparent, fair, and impactful data-driven solutions.

Indexed as

AIbig databig data analyticshealth equityimmune diseaseimmunologymachine learning

Identifiers

PMID41322981
PMCPMC12660090

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.