ArticleCureus2025
Radiographic Severity and Clinical Implications of Knee Osteoarthritis in Adults Under 55: Incidence and Insight Into Potential Candidates for Geniculate Artery Embolisation.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multimodality imaging considerations for genicular artery embolization in knee osteoarthritis.World journal of radiology · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKnee osteoarthritis (OA) increasingly affects adults well before traditional "older-age" brackets, raising questions about joint-preserving options. We evaluated radiographic OA severity among patients <55 years and considered the potential role of geniculate artery embolisation (GAE) for symptomatic management.
methodsThis was a retrospective cross-sectional study of consecutive outpatients (<55 years) referred to a Northern Ireland hospital with suspected knee OA. Anteroposterior radiographs were graded according to the Kellgren-Lawrence (KL) scale. Outcomes were the proportion with radiographic OA (KL≥2) and with moderate-to-severe OA (KL≥3).
resultsA total of 89 patients (mean age 47.5 years; range 35-54) were included in the study. The distribution of KL grades was as follows: grade 0 in 40.4%, grade 1 in 5.6%, grade 2 in 20.2%, grade 3 in 29.2%, and grade 4 in 4.5% of patients. Overall, 53.9% had radiographic osteoarthritis (KL ≥2), while 33.7% had moderate-to-severe disease (KL ≥3).
conclusionOver half of symptomatic outpatients under 55 had definite radiographic OA, and one-third had moderate-to-severe disease, highlighting a substantial disease burden in "younger" adults. Given joint-replacement deferral in this age group, GAE warrants evaluation within research pathways for persistent, treatment-refractory pain. The National Institute for Health and Care Excellence (NICE) currently recommends GAE only in research settings.
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