ArticleCureus2025
Primary Bone Sclerosing Epithelioid Fibrosarcoma: A Case Report and Literature Review.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sclerosing epithelioid fibrosarcoma (SEF) is an extremely rare soft tissue sarcoma. Primary involvement of the bone, particularly the spine, is exceptional, with only isolated cases described. We report a very rare case of primary spinal SEF occurring in a 30-year-old male who presented with chronic back pain. MRI revealed a mass involving the thoracic vertebrae. CT-guided biopsy showed a densely sclerotic stroma containing atypical spindle-to-epithelioid cells arranged in cords and nests. Immunohistochemistry demonstrated strong positivity for mucin-4 (MUC4) and epithelial membrane antigen, with negative staining for S100, desmin, and CK AE1/AE3, confirming the diagnosis of SEF. Surgical excision and spinal fixation were initially planned; however, the patient relocated abroad before surgery and instead received high-dose proton-beam radiotherapy alone. He remains under follow-up in 2024 without surgical intervention. This case emphasizes the significance of including primary bone SEF in the differential diagnosis of thoracic spinal masses, particularly in individuals experiencing chronic back pain. Timely identification and precise diagnosis with specific immunohistochemistry are crucial in guiding an appropriate treatment strategy. Our analysis of 38 cases, including our case, showed a male predominance, spinal involvement, and a high MUC4 positivity rate, reinforcing its role as a key diagnostic marker.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.