ReviewCureus2025
Exosomes as Central Mediators of Host-Pathogen Interactions in Periodontitis: A Systematic Literature Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The oral-gut-brain axis: how periodontitis influence depression.Frontiers in microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a chronic inflammatory disease that compromises the periodontium and is among the most prevalent oral conditions worldwide. Recent studies highlight exosomes - small extracellular vesicles carrying nucleic acids, lipids, metabolites, and proteins - as key mediators of intercellular communication contributing to disease progression. The objective of this review was to systematically analyze the existing scientific literature regarding the role of exosomes in the pathogenesis of periodontitis. This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The study question was formulated using the Population, Intervention, Comparison, and Outcome (PICO) framework: "Do exosomes contribute to the pathogenesis of periodontitis?". A literature search was performed in PubMed and ScienceDirect databases for articles published between 2015 and 2025. Inclusion criteria were restricted to original research, written in English, involving human participants or human-derived samples that explicitly focused on exosomes in the context of periodontitis. Out of 1,000 identified records, 106 full-text articles were screened, and six met the inclusion criteria. The included studies investigated salivary, gingival, or periodontal ligament stem cell-derived exosomes and reported their roles in pyroptosis, macrophage polarization, angiogenesis, and immune modulation. Key findings demonstrated that the downregulation of exosomal miR-223-3p enhanced NLRP3-mediated pyroptosis, while exosomal miR-143-3p promoted M1 macrophage polarization via the PI3K/AKT/NF-κB signaling pathway. In addition, exosomal VEGFA regulated by miR-17-5p promoted angiogenesis, and salivary exosomes exhibited immune-related protein cargo, decreased tetraspanins (CD9, CD81), and elevated PD-L1 mRNA in advanced disease. Collectively, this review underscores the ability of exosomes to transport diverse molecular cargo and influence recipient cell behavior, highlighting their role as mediators of intercellular communication in periodontal inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.