Evidence map›Paper›PMID 41322864›Full record

ArticleCureus2025

From Spider Bite to Fungating Ulcerating Mass: An Aggressive Squamous Cell Carcinoma of the Face.

Regina J McPherson, Juan Ramon Santos Rivera, Ilya Fonarov, Rodrigo Santoscoy-Valencia, Mehak Sharma

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Regina J McPhersonMedicine, Florida International University, Herbert Wertheim College of Medicine, Miami, USA.
Juan Ramon Santos RiveraInternal Medicine, Ponce Health Sciences University, Ponce, PRI.
Ilya FonarovInternal Medicine, Jackson Memorial Hospital, Miami, USA.
Rodrigo Santoscoy-ValenciaPathology and Laboratory Medicine, Jackson Memorial Hospital, Miami, USA.
Mehak SharmaInternal Medicine, Florida International University, Herbert Wertheim College of Medicine, Miami, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotic facial lesions can have variable presentations, including presenting as a secondary infection. We present a case of a progressively enlarging necrotic facial lesion in an HIV-positive patient. The patient reported the lesion began five months earlier after a presumed brown recluse spider bite. Despite initial debridement at another hospital, the wound continued to worsen, developing purulent and bloody discharge, escalating pain, and systemic symptoms. On examination, a fungating necrotic mass involving the right face was noted. Imaging suggested possible bony involvement, and biopsy confirmed poorly differentiated squamous cell carcinoma. This case highlights the diagnostic complexity of differentiating between chronic infectious processes and malignancy in immunocompromised patients. The patient's lack of HIV treatment and unstable living situation contributed to delayed care and advanced disease. Early dermatologic evaluation and biopsy of non-healing lesions are critical, particularly in populations facing medical and social vulnerabilities.

Indexed as

brown recluse spider bitefacial lesionhiv-associated malignancieshiv-related infectionpainful skin lesionssquamous cell carcinoma

Identifiers

PMID41322864
PMCPMC12664703

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.