ArticleCureus2025
Chronic Myeloid Leukemia Harboring a Novel Four-Way Variant Translocation t(7;22;9;15)(p15;q11.2;q34.1;q22) With Cryptic Double Philadelphia Chromosomes.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Variant Philadelphia chromosomes are occasionally observed in chronic myeloid leukemia. Among them, four-way variant Philadelphia translocations are particularly rare. Double Philadelphia chromosomes, representing an additional Philadelphia chromosome, are also uncommon and have been reported to be associated with disease progression and therapeutic challenges. We report a case of chronic myeloid leukemia with a novel four-way variant translocation t(7;22;9;15)(p15;q11.2;q34.1;q22) accompanied by cryptic double Philadelphia chromosomes. Despite these unfavorable cytogenetic features, the patient was successfully treated with dasatinib and achieved a complete hematologic response.
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