ReviewCureus2025
The Impact of Fracture Liaison Services on Outcomes in Older Patients: A Systematic Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporotic fractures are fractures caused by underlying osteoporosis that occur after minimal trauma. They represent a prevalent public health problem worldwide with significant economic burden and negative effects on quality of life. Fracture liaison services (FLS) are multidisciplinary programs aimed to decrease secondary fractures in high-risk patients by improving the post-fracture care gap. This review analyzes the impact of FLS on patient outcomes, especially refracture risk and osteoporosis medication initiation. This review was conducted using Ovid (MEDLINE), CINAHL, and Web of Science. Randomized controlled trials (RCTs), cross-sectional studies, observational studies, longitudinal studies, and cohort prospective/retrospective studies published between 2010 and 2024 were included. Selected articles also had a focus on refracture risk and/or osteoporotic medication initiation, a patient cohort mean age greater than 65 years old, and patients presenting with an initial osteoporotic fracture (as opposed to a history of fractures). Out of 727 total articles screened, 49 were included. The most prescribed medications were zoledronic acid, denosumab, and alendronate. FLS implementation was generally associated with a decrease in refracture rate, but only 11 out of 20 studies that assessed this found a statistically significant difference. Variability in refracture rates among studies may be due to differences in program intensity and patient demographics (namely, age and level of function). FLS can be an effective model to target the post-fracture care gap in older osteoporosis patients and improve outcomes, particularly medication initiation. Future studies should evaluate best practices for FLS programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.