ReviewCureus2025
Recent Trends in the Pharmacological Treatment of Chronic Migraine: A Systematic Review of Randomized Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic migraine is one of the debilitating neurological conditions affecting the lives of several patients. This systematic review aimed to explore the recent trends in the pharmacological treatment of chronic migraine. We conducted this systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The literature search encompassed extensive databases such as PubMed, ScienceDirect, and Cochrane Central Register of Controlled Trials. The analysis included studies published from 2014 to 2024, and the quality of the included studies was evaluated using the appropriate tools according to the study design. The synthesis and data analysis included a summary of study characteristics, interventions, outcomes measured, and main study results/conclusions. Sample sizes in the included studies ranged from 1,072 to 2,436 participants. The most common pharmacological treatments used for chronic migraine were eptinezumab, onabotulinumtoxinA, and galcanezumab, which emerged from 14 quality randomized controlled trials. Studies observed significant improvements across various metrics, including headache frequency, severity, quality of life measures, and patient-reported outcomes. The Headache Impact Test-6 score, monthly migraine headache days, Migraine-Specific Quality-of-Life score, and Migraine Disability Assessment score were particularly useful in quantifying the treatment's effectiveness. This systematic review concludes the effectiveness and safety of newer treatments such as eptinezumab, galcanezumab, and onabotulinumtoxinA in managing chronic migraine, illustrating notable improvements in both clinical outcomes and quality of life for patients.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.