ArticleCureus2025
Assessment of Thiol/Disulfide Homeostasis and Its Association With Clinical Manifestations in Behcet's Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behcet's disease (BD) is a multisystemic inflammatory vasculitis characterized by recurrent episodes of exacerbation and remission, with unpredictable duration and system involvement in each episode. Although previous studies have shown the role of oxidative stress in the pathogenesis of BD, the relationship between the clinical features of Behcet's disease and oxidative stress has not been fully studied to date. This study aims to assess the parameters of dynamic thiol disulfide homeostasis (DTDH) and their relationship with different clinical characteristics of disease in BD patients. Fifty patients with BD and 54 age and gender-matched healthy controls were included in the study. Disease activity was measured by the BD Current Activity Form. The mean total thiol (TT) levels were higher in BD patients compared to controls (p=0.04). The native thiol (NT) levels were lower in patients with BD compared to healthy individuals (p=0.014). Disulfide levels, disulfide/NT, and disulfide/TT levels were similar in both groups (all, p>0.05). No significant differences in DTDH parameters were observed based on the presence or absence of erythema nodosum, papulopustular lesions, venous thrombosis, arthritis/arthralgia, neurological involvement, pathergy test positivity, or HLA-B51 status (all, p>0.05). We found lower NT levels in patients with genital ulcers or eye involvement compared to those without these manifestations (p=0.036 and p=0.003, respectively). We observed similar DTDH parameters in patients with and without active disease, and in patients with and without current medical therapy (all, p>0.05). In addition, we found a negative relationship between disease duration and TT and NT levels (all, p<0.05). In conclusion, we demonstrated an imbalance of DTDH in the patients with BD, supporting the hypothesis that oxidative stress may contribute to the etiopathogenesis and progression of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.