ReviewFrontiers in molecular biosciences2025
The role of natural compounds in modulation of small extracellular vesicle biogenesis and lipid metabolism in cancer.
Review in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Phytochemical-Primed Extracellular Vesicles and Plant-Derived Exosome-Like Nanoparticles as Endogenous Nanomedicine Platforms.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small extracellular vesicles (sEVs) are vesicles of 15-150 nm in diameter secreted by cells and contain biological compounds that aid in cell growth, proliferation, and communication. Over the years, their role in oncogenesis has become prominent, especially in modulating the tumor microenvironment, facilitating epithelial-mesenchymal transition, and promoting metastasis. These oncosomes serve as unique diagnostic markers that can be used to detect specific types of cancer. Their stable lipid bilayer is composed of various classes of lipids, including phosphatidylserine, sphingomyelin, ceramides, and sterols. Alterations in the lipid profile of sEVs have been found in various chronic diseases, including cancers, making them suitable biomarkers and therapeutic targets. Natural compounds (NCs) derived from plants and microbes exhibit antitumorigenic properties. They have been recognized in contemporary medicine for their capacity to modulate sEV synthesis, secretion, and composition. However, there is limited research on the effects of NCs on the lipid panel of extracellular vesicles, as most studies have focused on proteins and microRNAs. Considering that NCs can influence key regulatory enzymes involved in lipogenesis and degradation, this suggests a potential impact on the lipid composition of sEVs. Therefore, we summarized the direct effects of NCs on sEVs and lipid-related enzymes, highlighting the potential for natural compound-mediated lipid modulation in sEVs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.