Evidence map›Paper›PMID 41322697›Full record

ReviewFrontiers in molecular biosciences2025

Advances in 3D bioprinting for modeling the blood-brain barrier in neurodegenerative diseases.

Shirleen Tan, Lifeng Qiu, Jolene Wei Ling Lee, Li Zeng

Abstract readReview
In one paragraph

Review in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shirleen Tan *Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.
Lifeng Qiu *Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.
Jolene Wei Ling LeeNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.
Li ZengNeural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing burden of neurodegenerative diseases (NDD) on healthcare systems, driven by global aging population, has increased interest in modelling the blood-brain barrier (BBB). While microfluidic platforms have been widely used to model the BBB, they remain limited by complex fabrication techniques, low-throughput, and restricted control over BBB geometry. Recent advancements in three-dimensional (3D) bioprinting offer promising strategies to overcome these constraints and to enable the generation of physiologically relevant BBB models. This review examines the recent progress in 3D bioprinting approaches to model human

Indexed as

3D bioprintingbioinkblood-brain barrierdisease modelingneurodegenerative diseases

Identifiers

PMID41322697
PMCPMC12657161

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.