ArticleACS omega2025
Novel Spontaneous Nanoemulsions for Phosphorus Selenide Compounds: Toward Enhanced Solubility and Stable Aqueous Formulations.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems.Chemical record (New York, N.Y.) · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organoselenium compounds have been extensively studied for their potential anticancer, hypoglycemic, antimicrobial, antioxidant, and anti-inflammatory properties. However, these compounds are highly lipophilic, restricts their solubility in organic solvents and limits their administration routes. Investigating surfactant interaction with organoselenium compounds offers opportunities to enhance formulation efficacy by increasing their bioavailability and water solubility through the formation of stable colloidal systems. In this study, phosphorus selenide compounds were mixed with three commonly used surfactants: cetyltrimethylammonium bromide (CTAB), sodium dodecyl sulfate (SDS), and Tween 20 (polysorbate 20). The resulting colloidal structures were characterized by ultraviolet-visible (UV-vis) spectroscopy, dynamic light scattering (DLS), ζ-potential (ZP), Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and atomic force microscopy (AFM). Improved apparent solubility was observed for all compounds, with aliphatic phosphorus selenide compounds exhibiting greater compatibility with the surfactants than aromatic variants. Formulations with SDS and CTAB were more stable than those with Tween 20, likely due to unfavorable electrostatic interactions between the nonionic surfactant and the phosphorus selenide compounds. Particle sizes ranging from 100 to 250 nm were measured and, together with conductivity and AFM analyses, indicated the formation of spontaneous nanoemulsions. Studying surfactant interactions with these compounds may improve formulations by reducing the required amount of active compound required, enabling more precise release. This approach also reduces reliance on organic solvents, thereby minimizing environmental impact and offering promising applications in diverse fields, including pharmaceuticals, pesticide formulations, and catalysis.
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Registered trials
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