ArticleACS omega2025
Polymeric Nanocarriers of a Monosubstituted Tetraphenylporphyrin Sensitizer Intended for Photodynamic Therapy and Tumor Imaging.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Natural Photosensitizers in Cancer Therapy: A Chemo-Biodiversity Perspective on Light-Activated Natural Compounds.Chemistry & biodiversity · 2026Review
- Polymeric Theranostics with Tetraphenylporphyrin for Effective Low-Dose Photodynamic Cancer Therapy.Pharmaceutics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To effectively combat advanced cancers, next-generation nanomedicines should combine both therapeutic and diagnostic functions. In this study, we developed stimulus-responsive theranostics systems based on micellar nanostructures that deliver derivatives of tetraphenylporphyrins (TPP) bound via tumor microenvironment-sensitive hydrazone bonds. These nanomedicines are engineered using a micelle-forming polymer-TPP conjugate, enabling the pH-sensitive activation of both photodynamic therapy (PDT) and fluorescence. Two pH-sensitive and one stable polymer-TPP conjugates were synthesized and characterized by size exclusion chromatography and TPP release rates. Micelle stability was evaluated using UV/vis spectroscopy, while fluorescence and singlet oxygen production were measured to determine their theranostics potential. Femtosecond transient absorption and time-correlated single photon counting techniques were employed for the photophysical evaluation of micellar systems. Compared to polymer conjugates where TPP is linked through nondegradable amide bonds, the pH-sensitive systems exhibit superior physicochemical properties. These micellar conjugates are highly stable, allowing prolonged circulation in the body while remaining in an "off" state, where fluorescence and singlet oxygen production are minimized. Overall, the hydrazone-linked conjugates display favorable properties that make them strong candidates for future anticancer theranostic applications.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.