Evidence map›Paper›PMID 41322634›Full record

ArticleACS omega2025

Elena Scaglione, Rosa Bellavita, Martina di Rosario, Lucia Falcigno, Giuseppe Mantova, Leonardo Continisio, Chiara Pagliuca, Mariateresa Vitiello, Stefania Galdiero, Roberta Colicchio and 2 more

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elena ScaglioneDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Rosa BellavitaDepartment of Pharmacy, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.ORCID https://orcid.org/0000-0003-2163-5163
Martina di RosarioDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Lucia FalcignoDepartment of Pharmacy, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
Giuseppe MantovaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Leonardo ContinisioDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Chiara PagliucaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Mariateresa VitielloDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Stefania GaldieroDepartment of Pharmacy, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.
Roberta ColicchioDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
Annarita FalangaDepartment of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.ORCID https://orcid.org/0000-0001-6538-8585
Paola SalvatoreDepartment of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.ORCID https://orcid.org/0000-0002-7294-9253

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a critical global health threat, driven largely by the misuse of antibiotics and the emergence of multidrug-resistant (MDR) pathogens. Antimicrobial peptides (AMPs) have emerged as promising alternatives to traditional antibiotics due to their broad-spectrum activity and low propensity for inducing resistance. This study presents the design, synthesis, and characterization of a novel fusion peptide, WMRK-gH625, which combines the antimicrobial activity of peptide WMR-K with the membrane-translocating capability of cell-penetrating peptide gH625. The hybrid peptide exhibited a helical conformation, enhanced membrane fusion and destabilization capabilities, and selective action against bacterial membranes without significant effects on eukaryotic cells. WMRK-gH625 demonstrated potent antimicrobial activity against both Gram-positive bacteria, including

Identifiers

PMID41322634
PMCPMC12658822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.