Evidence map›Paper›PMID 41322630›Full record

ArticleACS omega2025

Dual Mechanisms of Action of a Halogenated Allyl Fatty Acid against Methicillin-Resistant

Jazmar Villarini-Torres, Giancarlo Casillas-Vargas, Karama Shayeb, Alexis Rosado-Ortíz, Luzmarie Reyes-Vicente, Mayerli De Jesús-Vega, Derik Amely-Gavilán, Natasha Díaz-Cruz, Gil Cortés-Rodríguez, Jessica Said and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Enhancement of low-temperature growth ofbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jazmar Villarini-TorresDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Giancarlo Casillas-VargasDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Karama ShayebDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Alexis Rosado-OrtízDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Luzmarie Reyes-VicenteDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Mayerli De Jesús-VegaDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Derik Amely-GavilánDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Natasha Díaz-CruzDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Gil Cortés-RodríguezDepartment of Natural Sciences and Mathematics, Inter American University of Puerto Rico, Bayamón Campus, 500 Road Dr., John Will Harris, Bayamón, PR 00957, United States.
Jessica SaidDepartment of Chemistry and Biochemistry, Iona University, 715 North Avenue, New Rochelle, New York 10801, United States.
Jasmin Ceja-VegaDepartment of Chemistry and Biochemistry, Iona University, 715 North Avenue, New Rochelle, New York 10801, United States.
Elizabeth AndersenDepartment of Chemistry and Biochemistry, Iona University, 715 North Avenue, New Rochelle, New York 10801, United States.
Amani RabadiDepartment of Chemistry and Biochemistry, Iona University, 715 North Avenue, New Rochelle, New York 10801, United States.
Antonio ColomDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.
Harry RiveraDepartment of Natural Sciences and Mathematics, Inter American University of Puerto Rico, Bayamón Campus, 500 Road Dr., John Will Harris, Bayamón, PR 00957, United States.
Sunghee LeeDepartment of Chemistry and Biochemistry, Iona University, 715 North Avenue, New Rochelle, New York 10801, United States.ORCID https://orcid.org/0000-0003-2481-7982
Nataliya ChornaDepartment of Biochemistry, Medical Sciences Campus, University of Puerto Rico, P.O. Box 365067, San Juan, PR 00936, United States.
Kathleen BrundageDepartment of Microbiology, Immunology & Cell Biology, West Virginia University P.O. Box 9177, Morgantown, West Virginia 26506, United States.
Néstor M CarballeiraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, 17 Ave Universidad STE 1701, San Juan, PR 00925, United States.
David J Sanabria-RíosDepartment of Natural Sciences, Inter American University of Puerto Rico, Metropolitan Campus, P.O. Box 191293, San Juan, Puerto Rico 00919, United States.ORCID https://orcid.org/0000-0001-8797-1210

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Karen H Martin · 2018 to 2026
$22.4M
Investigating the mechanism of action of antibacterial synthetic unsaturated fatty acids in methicillin-resistant Staphylococcus aureusR15GM143681 · NIGMS · INTER AMERICAN UNIVERSITY/PUERTO RICO · PI SANABRIA, DAVID · 2024 to 2024
$405k
Special Becton Dickinson Fortessa Flow CytometerS10OD016165 · OD · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2013 to 2013
$384k
NIGMS NIH HHS P20 GM103434NIGMS NIH HHS P20 GM121322NIGMS NIH HHS R15 GM143681NIH HHS S10 OD016165
6 · The paper itself

Abstract

Antimicrobial resistance in MRSA demands agents with new mechanisms. We evaluated two synthetic unsaturated fatty acids, 2-hexadecynoic acid (2-HDA) and (

Identifiers

PMID41322630
PMCPMC12658796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.