Evidence map›Paper›PMID 41322628›Full record

ArticleACS omega2025

Synthesis and Antitrypanosomal Activity of Novel 2‑Nitroimidazole-3,5-Disubstituted Isoxazole Derivatives with Diaryl Ether and Thioether Substituents.

Larissa B B Santos, Diego B Carvalho, Cristiane Y K Shiguemoto, Omar D Lacerda, Talícia S Silva, Gisele B Portapilla, Saulo E Silva-Filho, Palimécio G Guerrero, Sérgio de Albuquerque, Adriano C M Baroni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Larissa B B SantosLaboratório de Síntese E Química Medicial (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Avenida Costa E Silva, s.n. Bairro Universitário, Campo Grande, Mato Grosso Do Sul 79070-900, Brazil.
Diego B CarvalhoLaboratório de Síntese E Química Medicial (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Avenida Costa E Silva, s.n. Bairro Universitário, Campo Grande, Mato Grosso Do Sul 79070-900, Brazil.
Cristiane Y K ShiguemotoLaboratório de Síntese E Química Medicial (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Avenida Costa E Silva, s.n. Bairro Universitário, Campo Grande, Mato Grosso Do Sul 79070-900, Brazil.ORCID https://orcid.org/0000-0002-3515-3272
Omar D LacerdaLaboratório de Síntese E Química Medicial (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Avenida Costa E Silva, s.n. Bairro Universitário, Campo Grande, Mato Grosso Do Sul 79070-900, Brazil.
Talícia S SilvaDepartamento de Análises Clínicas, Toxicológicas E Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Avenida Do Café, s.n. Monte Alegre, Ribeirão Preto, São Paulo 14040-903, Brazil.
Gisele B PortapillaDepartamento de Análises Clínicas, Toxicológicas E Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Avenida Do Café, s.n. Monte Alegre, Ribeirão Preto, São Paulo 14040-903, Brazil.
Saulo E Silva-FilhoFaculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Avenida Costa E Silva, s.n. Bairro Universitário, Campo Grande, Mato Grosso Do Sul 79070-900, Brazil.
Palimécio G GuerreroUniversidade Tecnológica Federal Do Paraná, Química, Rua Deputado Heitor Alencar Furtado, 4900, Curitiba, Paraná 81280-340, Brazil.
Sérgio de AlbuquerqueDepartamento de Análises Clínicas, Toxicológicas E Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Avenida Do Café, s.n. Monte Alegre, Ribeirão Preto, São Paulo 14040-903, Brazil.ORCID https://orcid.org/0000-0003-2530-9226
Adriano C M BaroniLaboratório de Síntese E Química Medicial (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos E Nutrição (FACFAN), Universidade Federal de Mato Grosso Do Sul (UFMS), Avenida Costa E Silva, s.n. Bairro Universitário, Campo Grande, Mato Grosso Do Sul 79070-900, Brazil.ORCID https://orcid.org/0000-0002-5371-3755

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we synthesized 17 novel 2-nitroimidazole-3,5-disubstituted isoxazole analogs of benznidazole with diaryl ether and thioether substituents and evaluated their antitrypanosomal activity and cytotoxicity. Compounds

Identifiers

PMID41322628
PMCPMC12658631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.