Evidence map›Paper›PMID 41322614›Full record

ArticleACS omega2025

NSAIDs beyond COX:

Airam Roggero, Pedro Mathias Loyola, Caroline Ramos da Cruz, Willian Haniel Bezerra de Carvalho Santos, Paloma Peixoto Borges, Adeilso Bispo Dos Santos Junior, Fábio Martins, Marcos A Oliveira, Sérgio F Sousa, Marcos H Toyama

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Airam RoggeroLAQV/REQUIMTEBioSIM, Department of Biomedicine, Medicine Faculty of Porto University, Porto District, Porto 4099-002, Portugal.ORCID https://orcid.org/0000-0003-4546-8013
Pedro Mathias LoyolaBIOMOLPEP, Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.ORCID https://orcid.org/0009-0009-4890-2410
Caroline Ramos da CruzBIOMOLPEP, Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.ORCID https://orcid.org/0000-0001-6509-5758
Willian Haniel Bezerra de Carvalho SantosBIOMOLPEP, Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.
Paloma Peixoto BorgesBIOMOLPEP, Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.
Adeilso Bispo Dos Santos JuniorBIOMOLPEP, Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.
Fábio MartinsLAQV/REQUIMTEBioSIM, Department of Biomedicine, Medicine Faculty of Porto University, Porto District, Porto 4099-002, Portugal.
Marcos A OliveiraLABIMEs Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.ORCID https://orcid.org/0000-0002-1192-7296
Sérgio F SousaLAQV/REQUIMTEBioSIM, Department of Biomedicine, Medicine Faculty of Porto University, Porto District, Porto 4099-002, Portugal.ORCID https://orcid.org/0000-0002-6560-5284
Marcos H ToyamaBIOMOLPEP, Department of Biology, Institute of Biosciences UNESP/CLP, São Paulo 11330-900, São Vicente, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for their cyclooxygenase (COX) inhibitory activity. However, mounting evidence suggests that their pharmacology extends beyond this canonical pathway. In this study, the potential of NSAIDs to modulate human acetylcholinesterase (AChE), a key enzyme linking neuroinflammation, metabolic dysfunction and degenerative diseases, was evaluated. An integrative strategy combining silicon and vitro approaches was employed. Structure-based molecular docking using GOLD, molecular dynamics simulations with AMBER21, and MM-GBSA free energy calculations were performed to assess binding stability and energetic favorability. Among the compounds that were tested, nimesulide displayed the highest binding affinity (Δ

Identifiers

PMID41322614
PMCPMC12658791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.