ArticleACS omega2025
Multifunctional Dynamic Hydrogel Based on a Micelle-Cross-Linked Chitosan Network for Infected Wound Healing.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Design, Properties and Applications of Multiple Dynamic Hydrogels.Materials (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite significant advancements in the development of hydrogel dressings for wound healing, there remains a highly urgent demand to create multifunctional hydrogels with satisfying biocompatibility, self-healing ability, adhesiveness, appropriate mechanical properties, antibacterial activity, and therapeutic effects. Herein, a versatile hydrogel dressing was prepared through the cross-linking of terminally aldehyde-modified Pluronic-F127 (AF127) micelles with dihydrocaffeic acid-functionalized chitosan (CA) via the formation of a dynamic Schiff base. The cooperation of chitosan grafted with multiple catechol groups and the dynamic nature of the Schiff base imparted the hydrogel with superior antioxidant properties, adhesiveness, rapid self-healing, intrinsic antibacterial activity, and pH-dependent responsiveness. The good adhesiveness and self-healing abilities, derived from the hydrogen bonding interactions of catechol groups and dynamic covalent bonds, enhance hydrogels' resistance to deformation. Moreover, after loading hydrophobic rhein into AF127 micelles, the hydrogel demonstrated potent anti-inflammatory effects and pH-responsive drug release, making it suitable for treating infected and inflammatory skin wounds. In vivo experiments showed that rhein-loaded CA/AF hydrogels significantly accelerated tissue regeneration, with an intact epidermis, enhanced collagen disposition, and increased angiogenesis in a full-thickness skin defect model infected by
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Registered trials
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