Evidence map›Paper›PMID 41322575›Full record

ArticleACS omega2025

Kaempferol Inhibits Colonic Contractions via L‑Type Voltage-Dependent Calcium Channels in Murine Smooth Muscle Cells.

Meng Yang, Rui Xiao, Wen Yu, Ying Wang, Sijia Chen, Song Zhao, Ziyu Liu, Jiayu Gu, Zibo Zhao, Xuanying Lyu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meng YangDepartment of Physiology, Medicine College, Jingchu University of Technology, Jingmen 448000, China.
Rui XiaoNational Demonstration Center for Experimental Basic Medical Science Education, Xuzhou Medical University, Xuzhou 221000, China.
Wen YuDepartment of First Clinical Medicine, Xuzhou Medical University, Xuzhou 221000, China.
Ying WangNational Demonstration Center for Experimental Basic Medical Science Education, Xuzhou Medical University, Xuzhou 221000, China.
Sijia ChenNational Demonstration Center for Experimental Basic Medical Science Education, Xuzhou Medical University, Xuzhou 221000, China.
Song ZhaoDepartment of First Clinical Medicine, Xuzhou Medical University, Xuzhou 221000, China.
Ziyu LiuDepartment of First Clinical Medicine, Xuzhou Medical University, Xuzhou 221000, China.
Jiayu GuDepartment of First Clinical Medicine, Xuzhou Medical University, Xuzhou 221000, China.
Zibo ZhaoDepartment of First Clinical Medicine, Xuzhou Medical University, Xuzhou 221000, China.
Xuanying LyuDepartment of Physiology, Medicine College, Jingchu University of Technology, Jingmen 448000, China.
Nina SongNational Demonstration Center for Experimental Basic Medical Science Education, Xuzhou Medical University, Xuzhou 221000, China.ORCID https://orcid.org/0000-0002-8633-3791

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kaempferol, a natural flavonoid in various herbs, exhibits many therapeutical effects of anti-inflammation, antitumor, antioxidation, and so on. While its therapeutic potential has been established in many diseases, Kaempferol's side effect on colonic motility and the underlying mechanism remains ambiguous. The colonic muscle strips from ICR mice were used in contractile experiments to explore the effects of Kaempferol on colonic contractions. Besides, a whole-cell patch technique was performed on the lysed cells from the colonic muscles to investigate the underlying mechanism of Kaempferol's inhibitory effects. It was found that Kaempferol could inhibit the contractions of colonic smooth muscle significantly. However, blocking the effect of the enteric nervous system or interstitial cells could not block the inhibitory effect of Kaempferol on colonic contractions. Besides, the agonist of the L-type calcium channel Bay K8644 could suppress the inhibiting effect of Kaempferol on colonic contractions. The whole-cell patch of smooth muscle cells shows that the Kaempferol inhibited the Ba currents via the L-type calcium channel. In conclusion, Kaempferol suppresses colonic contractions by inhibiting the L-type calcium channel in a smooth muscle cell, independent of enteric neurons, chloride channels, or potassium channels, which indicates its potential effects on colonic motility and underlying mechanisms.

Identifiers

PMID41322575
PMCPMC12658692

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.