Evidence map›Paper›PMID 41322543›Full record

ArticleACS omega2025

Optimization of Ultrasound-Assisted Extraction of (-)-Stepholidine from

Bruna Ribeiro de Lima, Kidney de Oliveira Gomes Neves, Lucas Apolinário Chibli, Ana Paula Alfaia Castro, Rebeca Dos Santos França, Giovana Anceski Bataglion, Marcos Batista Machado, Afonso Duarte Leão de Souza, Hector Henrique Ferreira Koolen, Maria Lúcia Belém Pinheiro and 1 more

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bruna Ribeiro de LimaDepartamento de Química, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0000-0002-6481-9213
Kidney de Oliveira Gomes NevesCentro de Apoio Multidisciplinar, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.
Lucas Apolinário ChibliDepartamento de Pesquisa e Desenvolvimento de Extratos Botânicos e Desidratados, Duas Rodas, 89251-901 Jaraguá do Sul, Santa Caterina Brazil.
Ana Paula Alfaia CastroCentro de Apoio Multidisciplinar, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0009-0008-2004-9000
Rebeca Dos Santos FrançaCentro de Apoio Multidisciplinar, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0000-0002-0256-4606
Giovana Anceski BataglionDepartamento de Química, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0000-0001-6643-9268
Marcos Batista MachadoDepartamento de Química, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0000-0002-8791-4803
Afonso Duarte Leão de SouzaDepartamento de Química, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0000-0001-7007-3991
Hector Henrique Ferreira KoolenEscola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, (UEA), 690065-130 Manaus, Amazonas, Brazil.
Maria Lúcia Belém PinheiroCentro de Apoio Multidisciplinar, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.
Felipe Moura Araújo da SilvaCentro de Apoio Multidisciplinar, Universidade Federal do Amazonas (UFAM), 69080-900 Manaus, Amazonas, Brazil.ORCID https://orcid.org/0000-0002-1809-1372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(-)-Stepholidine, a naturally occurring alkaloid found in the leaves of Onychopetalum amazonicum (Annonaceae), has shown significant pharmacological potential and serves as an important precursor in the synthesis of bioactive compounds. Currently, ultrasound-assisted extraction (UAE), combined with optimization through response surface methodology (RSM), has emerged as a promising strategy to enhance the efficiency of extraction processes. This study aimed to develop an efficient method for extracting (-)-stepholidine from the leaves of

Identifiers

PMID41322543
PMCPMC12658633

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.