ArticleACS omega2025
Enhanced Skin Delivery of Amphotericin B: Development and Evaluation of Polymeric Nanoparticles Using a Porcine Ear Model.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amphotericin B (AmB) is a widely used antifungal drug that is also prescribed to some neglected diseases, such as leishmaniasis. Its usage is limited by its low oral bioavailability and side effects, leading to the exploration of alternative delivery systems. Polymeric nanoparticles (PNPs) have emerged as a promising drug delivery pathway, offering potential benefits such as controlled release and improved drug bioavailability. In this work, AmB-loaded poly-(lactic acid) (PLA) and polycaprolactone (PCL) PNPs were produced by nanoprecipitation and characterized by dynamic light scattering, scanning transmission electron microscopy, and Raman spectroscopy. Subsequently, their stability was tested in static multiple light scattering (SMLS) analysis, and their penetrability was determined in an
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Registered trials
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