SynthesisFrontiers in cardiovascular medicine2025
CMR T1 reactivity in healthy adult hearts: a systematic review and meta-analysis.
Synthesis in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Background: Cardiac stress T1-mapping is an advanced magnetic resonance imaging technique that enables the detection of myocardial ischemia and coronary microvascular dysfunction without the need for gadolinium-based contrast agents (GBCAs). This review seeks to synthesize reported mean ΔT1 values from studies involving healthy adults, establish an approximate range of myocardial T1 reactivity in this population, and explore factors underlying the heterogeneity observed across different studies. Methods: PubMed, Web of Science, and Cochrane Central were searched for studies reporting myocardial T1 reactivity in healthy adult participants. The search strategy included terms such as: "Stress T1 'AND' Mapping" OR "Stress T1 'AND' Cardiovascular magnetic resonance" OR "Stress T1 'AND' CMR" OR "T1 reactivity 'AND' Cardiovascular magnetic resonance" OR "T1 reactivity 'AND' CMR." Use the Joanna Briggs Institute (JBI) quantitative critical appraisal tools for documentation quality assessment. The average value is summarized using the random effect model, and heterogeneity was assessed by using the inconsistency factor ( Results: This systematic review of T1 reactivity included 10 articles (11 study groups), with 226 participants (mean age, 52.21 years; 56.19% men [127 of 226]). The pooled mean of ΔT1 was 6.22% (95% confidence interval [CI]: 5.60, 6.84). Conclusions: This analysis summarizes the pooled means and CI of T1 reactivity in healthy adult participants. Significant heterogeneity was observed, highlighting the need to standardize cardiac MRI protocols and to investigate factors influencing T1 reactivity. Systematic Review Registration: identifier CRD42024568804.
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