ArticleFrontiers in cardiovascular medicine2025
Screening and characterization of natural extracts as dual-functional regulators for cardiomyocyte regeneration and cardiac repair.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Cardiovascular diseases (CVDs), the leading cause of global mortality, demand novel strategies to enhance cardiac regeneration. While ongoing research has begun to address the critical need for novel therapies aimed at regenerating cardiomyocytes in the context of cardiovascular disease, existing pharmacological interventions remain insufficient. This study was designed to systematically evaluate natural extracts for their potential to enhance cardiomyocyte differentiation and facilitate cardiac repair. Methods: We performed an extensive literature review and identified 22 natural extracts associated with cardiac regeneration and stem cell differentiation. Through the use of a Tnnt2H2B-mCherry reporter mouse embryonic stem cell (mESC) line, we determined that Ganoderma lucidum water extract (GLW) are potent inducers of cardiomyocyte differentiation both Results: GLW extracts significantly increased the proportion of beating cardiomyocytes, upregulated cardiac-specific markers (e.g., Tnnt2, Myh6), and enhanced the expression of key transcription factors (Isl1, Nkx2.5, Gata4, Mef2c) during cardiac progenitor cell (CPC) specification. Mechanistically, GLW modulated the Wnt signaling pathway, which is critical for CPCs specification. Conclusions: Our findings underscore the potential of GLW as promising candidates for dual-functional therapies targeting myocardial regeneration and injury mitigation, providing novel insights into natural product-based interventions for CVD management.
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