ArticleOpen life sciences2025
Lipoxin A4 improves myocardial ischemia/reperfusion injury through the Notch1-Nrf2 signaling pathway.
Article in Open life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
11 authors.
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Abstract
This study investigates the mechanism by which lipoxin A4 (LXA4) attenuates myocardial ischemia/reperfusion injury (MIRI). Using a rat MIRI model, we evaluated coronary flow, histopathology, cardiac enzymes (cTnI/CK-MB), oxidative stress markers (superoxide dismutase, SOD; malondialdehyde, MDA; glutathione peroxidase, GSH-Px), and protein expression (neurogenic locus notch homolog protein 1 [Notch1], hairy and enhancer of split 1 [Hes1], nuclear factor-erythroid 2-related factor 2 [Nrf2], β-tubulin). Pharmacological inhibitors
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