Evidence map›Paper›PMID 41322424›Full record

ArticleFrontiers in immunology2025

Gut microbiota dysbiosis and systemic inflammation in elderly Chinese hypertensive patients: a case-control study.

Yiwen Cheng, Yihua Huang, Zhangcheng Zhu, Wenwen Ding, Xia Liu, Xiaocui Xu, Yangtian Chen, Ling Wang, Longyou Zhao, Zongxin Ling and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yiwen Cheng *State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yihua Huang *Department of Nursing, Lishui Second People's Hospital, Lishui, Zhejiang, China.
Zhangcheng Zhu *Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Wenwen Ding *Department of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Jiangsu, China.
Xia Liu *Department of Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xiaocui XuDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Jiangsu, China.
Yangtian ChenDepartment of Anesthesiology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Jiangsu, China.
Ling WangDepartment of Nursing, Lishui Second People's Hospital, Lishui, Zhejiang, China.
Longyou ZhaoDepartment of Laboratory Medicine, Lishui Second People's Hospital, Lishui, Zhejiang, China.
Zongxin LingState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, China-Singapore Belt and Road Joint Laboratory on Infection Research and Drug Development, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Shiwei YeDepartment of Clinical Nutrition, Lishui Second People's Hospital, Lishui, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertension (HTN) remains the leading modifiable risk factor for global mortality and morbidity. The number of adults aged 30-79 with HTN has doubled worldwide, reaching approximately 1.3 billion, with nearly half unaware of their condition. Despite available therapies, the global control rate remains unacceptably low at around 20%, particularly in low- and middle-income countries. This substantial treatment gap contributes to a high burden of preventable cardiovascular events and strains healthcare systems globally, underscoring the urgent need for more effective, accessible, and personalized management strategies. Growing evidence suggests that gut microbiota dysbiosis plays a role in HTN pathogenesis, though its mechanistic basis remains incompletely understood. In this case-control study, we investigated the gut microbiota composition of 205 elderly Chinese individuals (153 HTN patients, 52 controls) using NovaSeq sequencing and assessed systemic inflammation using multiplex immunoassays. Enterotype analysis and receiver operating characteristic (ROC) modeling were employed to identify microbial signatures. HTN patients demonstrated significant β-diversity alterations and distinct taxonomic changes, characterized by enriched

Indexed as

DysbiosisGastrointestinal MicrobiomeHypertensionInflammationAgedBiomarkersCase-Control StudiesChinaEast Asian PeopleFemaleHumansMaleMiddle AgedBiomarkersBlautiaenterotypegut dysbiosishypertensioninflammation

Identifiers

PMID41322424
PMCPMC12657389

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.