ReviewJournal of conservative dentistry and endodontics2025
Role of aspartic acid and glutamic acid in dentin remineralization: A systematic review of emerging therapeutic approaches.
Review in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the systematic review was to evaluate the role of aspartic acid and glutamic acid in dentin remineralization, focusing on biomimetic strategies that use noncollagenous protein analogs. Registered with PROSPERO (CRD42024547624), this review searched PubMed/Medline, Web of Science, and Scopus up to February 2025 using PICO-based terms. In vitro studies investigating aspartic acid and glutamic acid in dentin remineralization were included. Study quality was assessed with the QUIN tool. Screening and selection were conducted independently by two reviewers followed by the data extraction and data synthesis. The systematic review was reported following the Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 guidelines. Out of 430 articles identified, 10 met the inclusion criteria. Quality assessment revealed 4 studies with low risk of bias, 5 with medium, and 1 with high risk. Aspartic acid and glutamic acid were identified to enhance hydroxyapatite crystallization and mechanical properties of dentin. The polymer-induced liquid-precursor process using poly-L-aspartic acid restored up to 91% of the elastic modulus in demineralized dentin. Glutamic acid improved both intrafibrillar and extrafibrillar mineralization, and its combination with tricalcium phosphate notably enhanced mineral deposition. Low-risk studies confirm that aspartic and glutamic acids effectively promote dentin remineralization by mimicking natural biomineralization processes, showing potential for clinical applications. Future research should aim to standardize these treatments through clinical trials to confirm their long-term efficacy and safety.
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Registered trials
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