ReviewJournal of conservative dentistry and endodontics2025
Revascularizing ability of platelet-rich fibrin in permanent necrotic immature teeth: A systematic review and meta-analysis.
Review in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Partial radicular versus coronal pulpotomy using chitosan and platelet-rich fibrin in vital permanent molars with irreversible pulpitis, with or without associated apical periodontitis: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2026Article
- Outcome evaluation of regenerative endodontic therapy using injectable-platelet-rich fibrin and platelet-rich fibrin in nonvital immature permanent teeth: A prospective observational study.Journal of conservative dentistry and endodontics · 2026Article
- Human amniotic membrane as an extracellular matrix scaffold in regenerative endodontics: A cell homing perspective.Journal of conservative dentistry and endodontics · 2026Review
- Assessment of regenerative endodontic procedures using platelet-rich fibrin in immature necrotic teeth.Bioinformation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To evaluate the efficacy of revascularizing ability of platelet rich fibrin (PRF) compared to other scaffolds in permanent necrotic immature teeth. Methods: Review was adhered to Preferred Reporting Items for Systematic Reviews and Meta Analysis (PRISMA) guidelines. A database search was conducted for studies comparing PRF to other scaffolds in inducing revascularization of permanent necrotic immature teeth. Quality assessment was performed using the Cochrane risk of bias 2 tool through Review Manager (RevMan) software version 5.3. Standardized mean difference (SMD) and odds ratio (OR) was used as summary statistic measure employing random effect model ( Results: Nine studies were taken for qualitative synthesis and five studies for meta analysis. PRF was compared to other scaffolds such as advanced PRF, blood clots, calcium hydroxide, mineral trioxide aggregate, platelet rich plasma and artificial scaffolds (collagen, placentrex, and chitosan) and reported outcomes as decrease in clinical signs (pain, swelling, and abscess), periapical healing, dentine wall thickness, increase in root length, increase in root width and decrease in apical foramen diameter. Meta analysis showed that PRF had greater periapical healing (OR = 1.11 [0.29-4.34]) and dentine wall thickening (OR = 3.68 [0.48-28.08]). Moreover, PRF showed greater increase in root length (SMD = 0.08 [-0.54-0.70]), increase in root width (SMD = 3.32 [-0.26-6.89]) and reduction in apical foramen diameter (SMD = 0.17 [-0.67-1.01]). Conclusion: Included studies showed a positive trend on the benefits of PRF. Regenerative endodontic procedures with PRF has shown high success rate in terms of periapical healing, dentine wall thickening and improved apical closure and can be concluded as a biologic and an economical adjunct exhibiting better results.
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