SynthesisFrontiers in pharmacology2025
Effect of intravitreal VEGF inhibitors on renal-related adverse events in patients with diabetes mellitus: systematic review and meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Intravitreal vascular endothelial growth factor inhibitors (VEGFis) are a standard treatment for diabetic eye complications. However, concerns persist regarding their potential nephrotoxic effects in patients with diabetes mellitus (DM), who are inherently at increased risk of renal disease due to diabetes-related microvascular damage. Methods: We systematically searched PubMed, Embase, and Cochrane Library for randomized controlled trials (RCTs) evaluating renal-related adverse events in DM adults receiving intravitreal VEGFis Results: From 16 RCTs (n = 5,930 patients), pooled analyses showed no significant increase in renal risk with VEGFis. The incidence of AKI (10 trials) showed no significant difference between the VEGFis groups (2.0%) and controls (1.5%; OR = 1.07, 95% CI: 0.65-1.75; GRADE very low quality). Similarly, the incidence of CKD (15 trials) was comparable in VEGFis groups (2.4%) Conclusion: Current evidence does not indicate a clear increase in the risk of AKI or CKD with intravitreal VEGFis in adults with DM, but the certainty is very low, and high-risk subgroups remain insufficiently studied.
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