ArticleJournal of pain research2025
Modulatory Effects of "Minor" Cannabinoids in an in vitro Model of Neuronal Hypersensitivity.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: Effective treatment for neuropathic pain remains an unmet clinical need. The therapeutic benefits of the Cannabis plant are well known, especially for pain relief. Here, we have assessed ten "minor" cannabinoids for their analgesic effects in an established model of neuronal hypersensitivity, a key mechanism which underlies neuropathic pain. Methods: Adult rat DRG neurons were cultured in medium containing 100 ng/mL nerve growth factor (NGF) and 50 ng/mL glial cell-line derived neurotrophic factor (GDNF) for 48 hours to sensitize the neurons. Ca Results: Control neurons (nociceptors) showed robust responses of Ca Conclusion: All the cannabinoids tested here inhibited TRPV1 signalling. CBC targeted K
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