ArticleFrontiers in medicine2025
Lichen planus with dysphagia: an interdisciplinary, monocentric study of quality of life and depression.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lichen planus (LP) is an inflammatory condition affecting skin and mucous membranes. Esophageal LP (ELP) is an underrecognized form causing dysphagia, with significant potential impact on patient quality of life. Objective: To comprehensively assess quality of life, health satisfaction, and psychological burden in LP patients with dysphagia, comparing outcomes between patients with confirmed ELP versus those with dysphagia attributed to oral LP (OLP) manifestations. Methods: Prospective cohort study conducted at the University of Freiburg Medical Center including 47 patients with LP presenting with dysphagia. Following comprehensive dermatological assessment and esophagogastroduodenoscopy with biopsy, patients were categorized into ELP ( Results: Nearly half of all patients (47%) expressed health dissatisfaction, with ELP patients showing significantly worse health satisfaction compared to non-ELP patients ( Conclusion: LP patients with dysphagia experience profound quality of life impairment and psychological distress, with nearly 9 in 10 patients showing signs of depression. ELP patients demonstrate significantly worse health satisfaction than non-ELP patients, yet current quality of life instruments inadequately assess ELP-specific burden. The alarming prevalence of psychological comorbidities, particularly among younger patients, necessitates routine mental health screening and integrated psychological support in LP management. These findings provide critical evidence supporting comprehensive, interdisciplinary treatment approaches and justify advanced therapeutic interventions for this challenging patient population.
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