Evidence map›Paper›PMID 41322192›Full record

ReviewMolecular therapy. Oncology2025

Rare but not forgotten: Therapeutic advancements for rare childhood cancers.

Jacquelyn N Crane, Urania Dagalakis, Robyn D Gartrell, Kris Ann P Schultz, Theodore W Laetsch

Abstract readReview
In one paragraph

Review in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jacquelyn N CraneDepartment of Pediatrics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Urania DagalakisDivision of Oncology, Cancer and Blood Disorders Center, Children's National Hospital, Washington, DC 20010, USA.
Robyn D GartrellDepartment of Oncology, Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21218, USA.
Kris Ann P SchultzCancer and Blood Disorders, Children's Minnesota, Minneapolis, MN 55404, USA.
Theodore W LaetschDepartment of Pediatrics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

LAB RESEARCH TRAINING IN PEDIATRIC ONCOLOGY-HEMATOLOGYT32CA060441 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN D FRIEDMAN · 1993 to 2026
$14.9M
Rare Tumor Clinical Research SpecialistR50CA305079 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Theodore Willis Laetsch · 2025 to 2026
$395k
NCI NIH HHS R50 CA305079NCI NIH HHS T32 CA060441
6 · The paper itself

Abstract

Cancers in children represent less than 1% of all new cases of cancer. While all cancers are rare during childhood, certain types are particularly rare. Multi-institutional pediatric trials and coordinated efforts between pediatric and adult groups have resulted in recent key advances in the treatment of certain rare pediatric cancers. This article reviews these advances with a focus on immunotherapies, molecularly targeted therapies, and radioligands. This includes work that led to the FDA approvals of immune checkpoint inhibitors in multiple rare pediatric tumor types, the NTRK inhibitors larotrectinib, entrectinib, and repotrectinib for children and adults with solid tumors with

Indexed as

adrenocortical carcinomaimmunotherapymelanomamolecular therapiesMT: Special Issue - Advancements in pediatric cancer therapynasopharyngeal carcinomaneuroendocrine tumorspeptide receptor radionuclide therapyrare pediatric cancerssarcomas

Identifiers

PMID41322192
PMCPMC12662008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.