Evidence map›Paper›PMID 41322190›Full record

ArticleMolecular therapy. Oncology2025

Mechanistic and functional characterization of ABTB2 as a novel target for pancreatic cancer therapy.

Nan Lyu, Olamide T Olaoba, Qiongling Wang, Harinarayanan Janakiraman, Xinjian Liu, Ernest Ramsay Camp, Kun Cheng, Eric T Kimchi, Yi Miao, Kevin F Staveley-O'Carroll and 1 more

Abstract read
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In one paragraph

Article in Molecular therapy. Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nan LyuDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.
Olamide T OlaobaDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.
Qiongling WangDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.
Harinarayanan JanakiramanDivision of Surgical Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Xinjian LiuDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.
Ernest Ramsay CampDivision of Surgical Oncology, Baylor College of Medicine, Houston, TX 77030, USA.
Kun ChengDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
Eric T KimchiDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.
Yi MiaoPancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Kevin F Staveley-O'CarrollDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.
Guangfu LiDepartment of Surgery, University of Missouri, Columbia, MO 65212, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BTB/POZ domain-containing proteins are increasingly recognized for their context-dependent roles in cancer, acting as either tumor suppressors or oncogenic drivers depending on the cancer type. Among them, the function of ankyrin repeat and BTB domain-containing protein 2 (ABTB2) in pancreatic ductal adenocarcinoma (PDAC), a highly lethal malignancy, has remained unexplored. In this study, we employed comprehensive functional genomics approaches-siRNA/shRNA knockdown, CRISPR-Cas9 knockout, plasmid-based overexpression, and a Cre-LoxP transgenic mouse model-to systemically modulate

Indexed as

ABTB2ankyrin repeat and BTB/POZ domain containing protein 2MT: Regular Issuepancreatic ductal adenocarcinomaPDACtargeted therapyTNF receptor associated protein 1TRAP1Wnt/β-catenin signaling pathway

Identifiers

PMID41322190
PMCPMC12664368

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.