Evidence map›Paper›PMID 41322149›Full record

ArticleMaterials today. Bio2025

Red blood cell-activated antifreeze metal-organic framework armor for cryopreservation.

Xin Li, Zhaoyang Gong, Muzhe Xu, Song Wang, Bingbing Sun

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xin LiState Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.
Zhaoyang GongState Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.
Muzhe XuState Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.
Song WangState Key Laboratory of Mesoscience and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China.
Bingbing SunState Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, 116024, Dalian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cell (RBC) cryopreservation is essential for maintaining ex vivo biological function and enabling long-term storage. However, the fragile nature of RBCs makes them highly susceptible to hemolysis during freezing and thaw cycles, limiting their widespread application. Here, a metal-organic framework (MOF)-based armor has been developed in a physiological environment, which enables one-step in situ encapsulation and unloading of RBCs. This MOF armor, functioning as a nano-bio interface, effectively shields RBCs from cryo-induced damage while preserving their native oxygen-carrying function. The MOF-armored RBCs not only inhibit ice recrystallization by restricting water molecule movement within the porous MOF structure but also serve as a "catalyst" to induce the smoothing of the ice front during growth, reducing sodium chloride eutectic formation and accelerating ice melting. Cryopreservation assays demonstrate exceptional RBC recovery (51 %) at a low MOF concentration (1 mg mL

Indexed as

Armored structureCryopreservationIce recrystallization inhibitionMetal-organic frameworksNano-bio interface

Identifiers

PMID41322149
PMCPMC12663683

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.