Evidence map›Paper›PMID 41322136›Full record

ArticleMaterials today. Bio2025

Neurofunctional MOF nanoparticles integrated with extracellular matrix hydrogel for neuro-Vascularized bone regeneration.

Ning Sheng, Runze Yang, Jie Wang, Wenting Wu, Man Zhe, Qing-Yi Zhang, Rong Nie, Long Chen, Fei Xing, Li Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Bone organoids and mitochondrial reprogramming.Journal of orthopaedic translation · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ning ShengDepartment of Orthopedics, Guizhou Provincial People's Hospital, Guiyang, 550000, Guizhou, People's Republic of China.
Runze YangDepartment of Orthopedics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.
Jie WangDepartment of Foot and Ankle Surgery, Honghui Hospital of Xi'an Jiaotong University, Xi'an City, Shaanxi, 710054, People's Republic of China.
Wenting WuDepartment of Pediatric Surgery, Division of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Man ZheAnimal Experiment Center, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Qing-Yi ZhangDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Rong NieDepartment of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Long ChenDepartment of Orthopedics, Guizhou Provincial People's Hospital, Guiyang, 550000, Guizhou, People's Republic of China.
Fei XingDepartment of Pediatric Surgery, Division of Orthopedic Surgery, Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.
Li SunDepartment of Orthopedics, Guizhou Provincial People's Hospital, Guiyang, 550000, Guizhou, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neural and vascular systems are the basic elements of bone. Neurovascular networks are widely distributed throughout the periosteum, cortical bone, and cancellous bone, which is highly significant for bone regeneration and remodeling. Reconstruction of the neurovascular network has been proposed as a therapeutic approach for bone defects. Here, a neuropeptide substance P-loaded nano-MOF combined with a double network hydrogel (PM@PS hydrogel) was applied to the bone regeneration environment to promote neuroangiogenesis by modulating Schwann cells (SCs) and human umbilical vein endothelial cells (HUVECs). It further enhances the osteogenic differentiation of bone marrow stromal cells (BMSCs) by activating the Wnt signaling pathway. In vivo experiments also demonstrate that functionalized hydrogels promote nerve ingrowth and vascularization, leading to neurovascular-driven bone regeneration. These findings emphasize the important role of the neurovascular network in bone regeneration and provide a new therapeutic strategy to facilitate the repair of critical-size bone defects.

Indexed as

Bone regenerationExtracellular matrixHydrogelNeuro-vascularizedSubstance PZn-MOF

Identifiers

PMID41322136
PMCPMC12663671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.