ArticleInternational journal of pediatrics2025
Clinical, Laboratory Characteristics, and Microorganism Infection Status in Neonates With Meningitis in Vietnam: A Cross-Sectional Descriptive Study.
Article in International journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study is aimed at describing the clinical and laboratory characteristics and determining the prevalence of microbial pathogens causing neonatal meningitis detected by cerebrospinal fluid (CSF) real-time polymerase chain reaction (PCR). Materials and Methods: A cross-sectional descriptive study was conducted on 55 neonates diagnosed with meningitis. Pathogens were identified by using CSF real-time PCR, CSF culture, or blood culture. Results: Late-onset meningitis accounted for 85.5% (47/55) of cases. The most common clinical signs were respiratory distress (56.4%), fever (47.3%), and lethargy (34.5%). The median white blood cell count was 13,560/mm Conclusion: Neonatal meningitis commonly manifests with respiratory distress, fever, and lethargy. While real-time PCR enables the detection of viral and rare pathogens, its limited overall detection rate underscores the importance of early diagnosis based on clinical presentation and CSF analysis rather than exclusive reliance on microbiological evidence, which may delay essential treatment.
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