Evidence map›Paper›PMID 41322075›Full record

ArticleDevice2025

Ethical, legal, and social issues related to ingestible, implantable electronic devices and mRNA delivery devices.

Lisa Bero, Natalie Banacos, Christine M Baugh, Peter R Chai, Tiffany R Glynn, Matthew DeCamp, Ben Harnke, Hannah Scotch, Jelena Durdic, Matthew Wynia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Device, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lisa BeroCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Natalie BanacosCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Christine M BaughCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Peter R ChaiDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Tiffany R GlynnDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Matthew DeCampCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ben HarnkeStrauss Health Sciences Library, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Hannah ScotchCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jelena DurdicCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Matthew WyniaCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Eric G CampbellCenter for Bioethics and Humanities, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Funding

Leveraging mHealth to develop syndemic-based behavioral medicine HIV prevention for the emergency department to reach people who use drugsK23DA060719 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI Tiffany Rose Glynn · 2024 to 2026
$599k
NIDA NIH HHS K23 DA060719
6 · The paper itself

Abstract

Oral delivery systems are being developed to treat disease, including ingestible devices that implant in the gut and deliver electrical stimulation or mRNA therapeutics. The implementation of these devices raises questions about the associated ethical, legal, and social implications (ELSIs). Our scoping review examined 83 scholarly publications published between 1946 and 2024 that investigate ELSI topics around the development and use of these technologies. We highlight the characteristics of the publications, the ethics topics mentioned, and a content analysis to describe ELSI themes. Themes particularly relevant to ingestible, implantable electronics and mRNA delivery devices were data use, invasiveness, and possible impacts on patient-clinician trust. This review suggests solutions to better protect patients from ethical and clinical risks resulting from data misuse and future empirical research engaging clinicians, patients, and researchers in this field.

Identifiers

PMID41322075
PMCPMC12662714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.