Evidence map›Paper›PMID 41322005›Full record

ArticleComputational and structural biotechnology journal2025

Komlan Atitey, Caitlin E Hughes, Joseph C Fusco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Komlan AtiteyBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences (NIEHS), 111 T W Alexander Dr Rall Building, Research Triangle Park, NC 27709, United States.
Caitlin E HughesDepartment of Pathology, Microbiology and Immunology, Monroe Carell Jr Children's Hospital at Vanderbilt, 2200 Children's Way Nashville, TN 37232, United States.
Joseph C FuscoDepartment of Pediatric Surgery, Monroe Carell Jr Children's Hospital at Vanderbilt, 2200 Children's Way Nashville, TN 37232, United States.

Funding

Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
NCI NIH HHS K12 CA090625
6 · The paper itself

Abstract

Identifying patient-specific cancer driver genes and their upstream modulators remains challenging due to temporal heterogeneity and the lack of matched multi-omics data. Existing methods often rely on large cohorts with DNA or perturbation assays, treat gene expression as static correlation rather than directed influence, or recover broad regulatory modules without resolving causal, time-resolved driver-modulator relationships. To overcome these limitations, we introduce

Indexed as

Cancer driver genesGene regulatory networksLung adenocarcinomaNon-driver regulatorsSingle-cell RNA-seqVariational Bayesian inference

Identifiers

PMID41322005
PMCPMC12664076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.