ArticleInternational journal of molecular and cellular medicine2025
Vitamin E incorporated in Carboxymethyl Cellulose-Gelatin Hydrogel Increases Wound Healing.
Article in International journal of molecular and cellular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Improving wound care products to facilitate effective skin repair is very important. Hydrogels are promising polymer-based dressings that enhance wound healing. Vitamin E can improve skin injuries by increasing antioxidant capacity. This study aimed to construct an innovative hydrogel from carboxymethyl cellulose (CMC) and gelatin (Gel) containing vitamin E to enhance wound healing. Five unique hydrogel formulations were constructed by combination of CMC-Gel and 25, 50, 100, and 200 µL/mL of Vitamin E. Structural characteristics of hydrogels were assessed using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). Biochemical properties of hydrogels, including swelling, weight loss, pH values, and blood compatibility, were evaluated by specific methods. The cytotoxicity effects of hydrogels on the NIH-3T3 fibroblasts were determined by MTT assay. The therapeutic potential of the hydrogels was investigated using a full-thickness wound model in Wistar rats. The constructed CMC-Gel-Vit E hydrogel had a porous structure characterized by interconnected voids measuring 73.15±9.61 µm, which is favorable for promoting cell migration. The cytotoxicity results showed no toxicity effects of hydrogels with and without VitE 100 µL/mL, also a survival rate of over 120% in cells after 72 h. In vivo data showed the CMC-Gel-Vit E hydrogel (91.36±8.23%) significantly increased the percentage of wound closure and re-epithelialization compared to the control group (68.31±13.59%). The results highlight the considerable potential of the CMC-Gel-VitE hydrogel as a viable option for skin regeneration and wound healing. This hydrogel exhibits substantial promise for use in clinical and therapeutic interventions.
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