Evidence map›Paper›PMID 41321971›Full record

ArticleInternational journal of molecular and cellular medicine2025

Investigating the role of transforming growth factor-beta/transforming growth factor-beta receptor in the development of hepatocellular carcinoma through the Salvador-Warts-Hippo pathway.

Samaneh Moradi, Radhwan Abdul Kareem, Hayder Naji Sameer, Soofi Dadkhoda, Ahmed Yaseen, Zainab H Athab, Mohaned Adil, Maryam Jamali Hondori, Hossein Gandomkar

Abstract read
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In one paragraph

Article in International journal of molecular and cellular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Samaneh MoradiDepartments of Internal Medical, Shiraz University of Medical Sciences, Shiraz, Iran.
Radhwan Abdul KareemAhl Al Bayt University, Kerbala, Iraq.
Hayder Naji SameerCollage of Pharmacy, National University of Science and Technology, Dhi Qar, 64001, Iraq.
Soofi DadkhodaDepartment of Medicine, Zabol University of Medical Science, Zabol, Iran.
Ahmed YaseenGilgamesh Ahliya University, Baghdad, Iraq.
Zainab H AthabDepartment of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.
Mohaned AdilPharmacy college, Al-Farahidi University, Iraq.
Maryam Jamali HondoriDepartment of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Hossein GandomkarDepartment of Surgical Oncology, Tehran University of Medical Medicine, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A key component of the Hippo signaling pathway (HSP) is a kinase cascade that connects the tumor suppressor Hippo to the oncoprotein Yki (YAP and TAZ). This oncoprotein functions as a transcriptional coactivator for target genes that play critical roles in cell proliferation and survival. The objective of this study is to evaluate the interaction between TGF-β proteins and key components of the Hippo signaling pathway in regulating hepatocellular carcinoma (HCC) cell behavior

Indexed as

Hepatocellular carcinoma (HCC)Hippo signaling pathway (HSP)Salvador-Warts-Hippo (SWH) pathwayTransforming growth factor-beta (TGF-β)

Identifiers

PMID41321971
PMCPMC12664695

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.