Evidence map›Paper›PMID 41321955›Full record

ArticleDEN open2026

Inhibitory Effect of Lidocaine on Duodenal Peristalsis During Endoscopic Retrograde Cholangiopancreatography: A Multicenter, Randomized Controlled Trial (With Video).

Masato Suzuki, Yusuke Sekino, Kunihiro Hosono, Yusuke Kurita, Hiroki Uechi, Kento Kuzuu, Shiori Uchiyama, Kenichi Kawana, Hajime Nagase, Kensuke Kubota and 2 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07333859 (Effect of Intravenous Lidocaine Infusion on Duodenal Peristalsis, Sedation Quality and Rescue Spasmolytic Requirement in ERCP Procedures), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07333859 phase4completednot on this map

Effect of Intravenous Lidocaine Infusion on Duodenal Peristalsis, Sedation Quality and Rescue Spasmolytic Requirement in ERCP Procedures: A Randomized, Double-Blind, Placebo-Controlled Study

TypeinterventionalSponsorAnkara City Hospital BilkentRan2026 to 2026Enrolled120ConditionsDuodenal Spasm, ERCP, SedationArmsLidocaine Hydrochloride 2%, 0.9 % Normal Saline
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Masato SuzukiDepartment of Gastroenterology National Hospital Organization Yokohama Medical Center Kanagawa Japan.ORCID https://orcid.org/0000-0001-9056-2768
Yusuke SekinoDepartment of Gastroenterology Yokohama Rosai Hospital Kanagawa Japan.
Kunihiro HosonoDepartment of Gastroenterology Yokosuka General Medical Center Kanagawa Japan.
Yusuke KuritaDepartment of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Kanagawa Japan.ORCID https://orcid.org/0000-0003-2482-6707
Hiroki UechiDepartment of Hepatobiliary and Pancreatic Medicine NTT Medical Center Tokyo Tokyo Japan.
Kento KuzuuCenter For Digestive Disease and Inflammatory Bowel Disease (IBD) Ofuna Chuo Hospital Kanagawa Japan.
Shiori UchiyamaDepartment of Gastroenterology Yokohama Rosai Hospital Kanagawa Japan.
Kenichi KawanaDepartment of Gastroenterology Sagamihara Municipal Hospital Kanagawa Japan.
Hajime NagaseDepartment of Gastroenterology Yokohama Rosai Hospital Kanagawa Japan.
Kensuke KubotaDepartment of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Kanagawa Japan.ORCID https://orcid.org/0000-0001-6767-0410
Masato YonedaDepartment of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Kanagawa Japan.
Atsushi NakajimaDepartment of Gastroenterology and Hepatology Yokohama City University Graduate School of Medicine Kanagawa Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Conventional antispasmodics used during endoscopic retrograde cholangiopancreatography (ERCP), such as hyoscine butylbromide and glucagon, are often contraindicated in elderly patients with comorbidities. This trial aimed to assess the efficacy of lidocaine for inhibiting duodenal peristalsis during ERCP. Methods: This multicenter randomized controlled trial enrolled 40 elderly patients (aged 65-89 years) who were scheduled to undergo ERCP. Patients were randomly assigned to the lidocaine group or the control group using a computer-generated sequence with stratification by age and sex. The lidocaine group ( Results: Eighteen patients from the lidocaine group and 19 patients from the control group were analyzed for the primary outcome. The inhibition rate of duodenal peristalsis was significantly higher in the lidocaine group (94.4%) than in the control group (52.6%) ( Conclusions: In our limited cohort, lidocaine inhibited duodenal peristalsis during ERCP without adverse events, suggesting its potential as a safe and practical option (jRCT No. 031190059).

Indexed as

elderlyendoscopic retrograde cholangiopancreatographylidocaineperistalsisrandomized controlled trial

Identifiers

PMID41321955
PMCPMC12660053

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.